Director of Research (if dissertation) or Advisor (if thesis)
Popescu, Gabriel
Department of Study
Electrical & Computer Eng
Discipline
Electrical & Computer Engr
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
M.S.
Degree Level
Thesis
Date of Ingest
2011-01-14T22:46:09Z
Keyword(s)
Quantitative Phase Imaging
Blood Cytometry
Interferometry
Single Cell Morphology
Abstract
Blood smear analysis has remained a crucial diagnostic tool for pathologists despite the
advent of automatic analyzers such as flow cytometers and impedance counters. Though these
current methods have proven to be indispensable tools for physicians and researchers alike, they
provide limited information on the detailed morphology of individual cells and merely alert the
operator to manually examine a blood smear by raising flags when abnormalities are detected.
Here I demonstrate an automatic interferometry based smear analysis technique known as
Diffraction Phase Cytometry (DPC), which is capable of providing the same information on red
blood cells as is provided by current clinical analyzers, while rendering additional, currently
unavailable parameters on the 2D and 3D morphology of individual red blood cells (RBCs). To
validate the utility of the technique in a clinical setting, I present a comparison between tests
generated from 32 patients by a state-of-the-art clinical impedance counter and DPC.
The majority of work presented in this thesis is drawn from two publications: M. Mir et
al., Journal of Biomedical Optics, vol. 15 (2), 2010, and M. Mir et al. Optics Express, vol. 17,
2009.
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Mir_Mustafa.pdf
