The effects of alterations in internal Ca levels on cat small intestinal slow waves

Mangel, Allen W.

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https://hdl.handle.net/2142/18820 Copy

Description

Title

The effects of alterations in internal Ca levels on cat small intestinal slow waves

Author(s)

Mangel, Allen W.

Issue Date

1980

Director of Research (if dissertation) or Advisor (if thesis)

Connor, John A.

Doctoral Committee Chair(s)

Connor, John A.

Committee Member(s)

• Arntzen, Charles J.
• Sherwood, O. David
• Prosser, C. Ladd
• Curtis, Brian A.

Department of Study

Physiology

Discipline

Physiology

Degree Name

Ph.D.

Degree Level

Dissertation

Keyword(s)

• Physiology
• Cats
• Animals

Language

en

Abstract

Control of slow wave frequency in cat small intestinal muscle was investigated with microelectrodes. Exposure of intact muscle or isolated longitudinal muscle to low Ca('2+) saline decreased slow wave frequency with less than a 6 mV change in resting potential. This frequency decline was characterized by a prolongation of the diastolic phase of the slow wave. Raising Ca(,0)('2+) to 2-3 times normal increased slow wave frequency. At Ca(,0)('2+) greater than 4 times normal, the slow wave frequency again decreased. However, this decrease in frequency was characterized by a prolongation of the systolic phase of the waveform. Application of Ca conductance blockers (Co('2+), Mn('2+), D600, verapamil), increasing Mg(,0)('2+) or increasing internal pH decreased slow wave frequency by a prolongation of the diastolic region of the slow wave. Addition of db-cAMP to Krebs saline made hypertonic with sucrose or decreasing internal pH increased slow wave frequency. These results indicate a relationship between internal Ca('2+) and the pacemaker of slow wave frequency. A scheme is proposed to explain that relationship.

Type of Resource

text

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http://hdl.handle.net/2142/18820

Copyright and License Information

Copyright 1980 Allen Wayne Mangel

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