University of Illinois Urbana-Champaign

Magnetic resonance characterization of gadolinium-based contrast agents

Hwang, Jong-Hee

Content Files
9114276.pdf

Permalink

https://hdl.handle.net/2142/21068

Description

Title
Magnetic resonance characterization of gadolinium-based contrast agents
Author(s)
Hwang, Jong-Hee
Issue Date
1990
Doctoral Committee Chair(s)
Belford, R. Linn
Department of Study
Chemistry
Discipline
Chemistry
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Date of Ingest
2011-05-07T12:57:25Z
Keyword(s)
Chemistry, Physical
Language
eng
Abstract
  • Several magnetic resonance methods have been used for characterizing gadolinium-based contrast agents in NMR Imaging in this thesis. Many Gd-based contrast agents were studied including Gd DTPA(dimethylenetriaminepentaacetic acid). The zero field splitting energies and g values of Gd complexes were obtained in frozen solutions by the EPR technique. Solvent structures of Gd-based contrast agents were studied by the ESE(Electron Spin Echo) method. Analysis of $\sp2$H-ESEEM of Gd TTHA(trimethylenetetraaminehexaacetic acid) demonstrated the existence of the second sphere water. The distance between $\sp2$H-Gd, a$\sb{\rm iso}$, and quadrupolar coupling constants were obtained by computer simulations of $\sp2$H-ESEEM of Gd complexes in frozen solutions. Water exchange times between the Gd complexes and bulk water were studied by O-17 NMR. However, it was found that the direct application of the Merbach method to the Gd-based contrast agent system showed some limitations. NMRD(Nuclear Magnetic Resonance Dispersion) studies provided useful information when combined with many other techniques. Data from NMRD simulations were well correlated with ones from EPR, ESEEM, and O-17 NMR. As a result, the combination of several techniques made NMRD analysis more reliable.
  • In the last chapter, the results of low osmolar Gd-based contrast agents studies are described. NMRD measurements were done in water and human plasma. Some of the Gd complexes showed binding behavior with plasma proteins, especially albumin. This binding affinity seems to be varied depending on the balance between the hydrophilic and lipophilic groups in one compound.
Type of Resource
text
Permalink
http://hdl.handle.net/2142/21068
Copyright and License Information
Copyright 1990 Hwang, Jong-Hee

Owning Collections

Graduate Dissertations and Theses at Illinois PRIMARY
Graduate Theses and Dissertations at Illinois
Dissertations and Theses - Chemistry