University of Illinois Urbana-Champaign

Age-related impairments in memory and in cholinergic signaling due to reduced blood glucose responses to epinephrine

Morris, Kenneth

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Kenneth_Morris.pdf

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https://hdl.handle.net/2142/42331

Description

Title
Age-related impairments in memory and in cholinergic signaling due to reduced blood glucose responses to epinephrine
Author(s)
Morris, Kenneth
Issue Date
2013-02-03T19:35:34Z
Director of Research (if dissertation) or Advisor (if thesis)
Gold, Paul E.
Doctoral Committee Chair(s)
Gold, Paul E.
Committee Member(s)
  • Korol, Donna L.
  • Beverly, Joseph L.
  • Chung, Hee Jung
  • Galvez, Roberto
Department of Study
School of Molecular & Cell Bio
Discipline
Neuroscience
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Date of Ingest
2013-02-03T19:35:34Z
Keyword(s)
  • Memory
  • Aging
  • Glucose
  • Epinephrine
  • Acetylcholine
  • Hippocampus
  • cAMP response element binding protein (CREB)
Abstract
Memory impairments accompany aging and can range in severity from mild deficits during healthy aging to debilitating conditions such as Alzheimer’s disease. The causes of these impairments are generally viewed in terms of anatomical, chemical, and physiological changes within the brain. However, age-related changes in peripheral neuroendocrine systems can alter central neurobiological processes and may underlie some types of memory deficits. Previous work in rodents and humans indicates that increases in blood glucose in response to endogenous epinephrine release are important for regulating memory formation and durability. In old rats, glucose is less responsive to epinephrine and becomes severely depleted in the extracellular fluid of the hippocampus during a cognitively demanding task, contributing to poor memory. Glucose supplementation restores extracellular fluid levels of glucose and reverses the associated memory impairments. The present work examines potential mechanisms by which reduced blood glucose responses to epinephrine may produce age-related memory impairments, with particular emphasis on the ability of exogenously administered epinephrine or glucose to attenuate deficits in memory processes. Several findings suggest fluctuations in glucose levels in the extracellular fluid may modulate memory processes by altering the release of the neurotransmitter acetylcholine, which may affect downstream processes important for the formation of durable memories. In particular, nicotinic acetylcholine receptor signaling mediates the calcium-dependent activation of the ERK/MAPK and CREB signaling cascades, which are widely implicated in activity-dependent neuronal plasticity. Age-related deficits in brain glucose availability may limit these cholinergic signaling processes and produce memory impairments. This is the major hypothesis guiding these studies.
Graduation Semester
2012-12
Permalink
http://hdl.handle.net/2142/42331
Copyright and License Information
Copyright 2012 Kenneth Allen Morris

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Graduate Dissertations and Theses at Illinois PRIMARY
Graduate Theses and Dissertations at Illinois
Dissertations - Neuroscience