University of Illinois Urbana-Champaign

Amino Acid Limitation Induces the Amino Acid Response (AAR) Pathway in a Time-and Species-Specific Manner

Anderson, Heather; Wang, Huan; Li, Qian; Pan, Yuan-Xiang; Chen, Hong

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amino acid limitation induces the amino acid response pathway in a time and species specific manner.pdf

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https://hdl.handle.net/2142/66348

Description

Title
Amino Acid Limitation Induces the Amino Acid Response (AAR) Pathway in a Time-and Species-Specific Manner
Author(s)
  • Anderson, Heather
  • Wang, Huan
  • Li, Qian
  • Pan, Yuan-Xiang
  • Chen, Hong
Issue Date
2014
Keyword(s)
  • amino acid limitation
  • AAR
  • human
  • rat
  • hepatoma
  • HepG2
Date of Ingest
2014-12-12T21:53:52Z
Abstract
Amino acids are critical to life and play central roles both as building blocks of proteins and as intermediates in metabolism. The amino acid response (AAR) pathway is activated by lacking of amino acids (i.e. amino acid starvation). We hypothesized that the activation of AAR pathway might occur in a time-dependent manner in hepatoma cells, which might induce restriction of protein production from DNA. Real-time RT-PCR was used to investigate mRNA expressions during this process. Our results showed that expression of Atf3, Chop, and Asns genes were induced significantly by amino acid deprivation in a time- and species- dependent manner.
Type of Resource
text
Genre of Resource
Article
Language
en
Permalink
http://hdl.handle.net/2142/66348
Copyright and License Information
Copyright 2014 Heather Anderson, Huan Wang, Qian Li, Yuan-Xiang Pan, Hong Chen

Owning Collections

i-ACES - Vol. 1, no. 1 2014 PRIMARY