Studies of Reaction Mechanisms Requiring Low Molecular Weight Thiol Cofactors
Frick, Thomas Dennison
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Permalink
https://hdl.handle.net/2142/67402
Description
Title
Studies of Reaction Mechanisms Requiring Low Molecular Weight Thiol Cofactors
Author(s)
Frick, Thomas Dennison
Issue Date
1980
Department of Study
Biochemistry
Discipline
Biochemistry
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Chemistry, Biochemistry
Language
eng
Abstract
The methyl-transfer reaction between methylcobalamin and 2-mercapto-ethanesulfonic acid (Coenzyme M) was investigated. We propose that this reaction is a thiyl radical promoted homolytic cleavage of the cobalt-carbon bond rather than the nucleophilic attack by thiolate anion which has been pro
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