Self-assembly of bioactive or electrocatalytic polyaspartamide nanoparticles

Lai, Mei-Hsiu

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https://hdl.handle.net/2142/73039 Copy

Description

Title

Self-assembly of bioactive or electrocatalytic polyaspartamide nanoparticles

Author(s)

Lai, Mei-Hsiu

Issue Date

2015-01-21

Director of Research (if dissertation) or Advisor (if thesis)

Kong, Hyun Joon

Doctoral Committee Chair(s)

Kong, Hyun Joon

Committee Member(s)

• Murphy, Catherine J.
• Schroeder, Charles M.
• Zhao, Huimin

Department of Study

Chemical & Biomolecular Engr

Discipline

Chemical Engineering

Degree Granting Institution

University of Illinois at Urbana-Champaign

Degree Name

Ph.D.

Degree Level

Dissertation

Keyword(s)

• polyaspartamide
• near-infrared (NIR) fluorescence imaging
• enhanced permeability and retention (EPR) effect
• polymeric vesicles (polymersomes)
• polymeric micelles
• surface plasmon resonance (SPR) spectroscopy

Abstract

Submicrometer sized particles are being extensively studied because of their potentials to deliver various molecular drugs and imaging contrast agents to target diseased tissue and also support electrocatalytic activities of metallic particles. Successful use of nanoparticles in these biological and energy applications greatly depends on the ability to control the structural integrity and the surface functionality of nanoparticles. Innumerable methods to assemble bioactive or electrocatalytic nanocarriers were proposed to dates; however, most approaches accompany complex chemistry and multiple purification, thus reducing production yield while increasing costs. Therefore, the goal of this thesis research was to develop a simple but advanced method to control the lifetime and surface functionality of nanocarriers. Along this line, the thesis presents three different approaches: 1) To extend bioavailability of nanocarriers labeled with a near infrared (NIR) probe by decreasing the nanoparticle bilayer permeability and subsequently enhance the quality of tumor detection (Chapter 2); 2) To functionalize the nanocarrier surface with a wide array of antibodies in a simple yet elaborate bio-inspired approach (Chapter 3); 3) To improve electrocatalytic activities of polymeric micelles via surface coating with platinum nanocubes (Chapter 4). Overall, the results of this thesis study would greatly serve to allow us to engineer the function of nanocarriers in a simple and economic manner, and expedite their uses in a wide array of applications.

Graduation Semester

2014-12

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http://hdl.handle.net/2142/73039

Copyright and License Information

Copyright 2014 Mei Lai

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