Colloidal Gold as Molecular Capture Devices in Hybrid Nano/microfluidic Systems for Mass-Limited Sample Analysis
Kirk, John Samuel, VIII
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https://hdl.handle.net/2142/84212
Description
Title
Colloidal Gold as Molecular Capture Devices in Hybrid Nano/microfluidic Systems for Mass-Limited Sample Analysis
Author(s)
Kirk, John Samuel, VIII
Issue Date
2005
Doctoral Committee Chair(s)
Bohn, Paul W.
Department of Study
Chemistry
Discipline
Chemistry
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Chemistry, Analytical
Language
eng
Abstract
Analyte capture by the colloidal gold was demonstrated in a hybrid nano/microfluidic device designed for sequential fluid manipulations in three dimensions. A nanocapillary array membrane (NCAM) was utilized to enable efficient mixing of the gold colloid and the adsorbate in-device. Fluorescence microscopy was used to monitor fluorescence quenching during monolayer self-assembly of analytes on the colloidal gold surface. The kinetics of the heterogeneous reaction was fit using a second order reversible kinetics model and the adsorption rate constant was compared to reported values for thiols on planar gold substrates.
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