Identification and Biological Evaluation of Coactivator Binding Inhibitors for the Estrogen Receptor
Gunther, Jillian Rebecca
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Permalink
https://hdl.handle.net/2142/84343
Description
Title
Identification and Biological Evaluation of Coactivator Binding Inhibitors for the Estrogen Receptor
Author(s)
Gunther, Jillian Rebecca
Issue Date
2009
Doctoral Committee Chair(s)
Katzenellenbogen, John A.
Department of Study
Chemistry
Discipline
Chemistry
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Chemistry, Biochemistry
Language
eng
Abstract
Finally, the determination of the ER status of a tumor is invaluable in choosing most effective treatment for a breast cancer patient. In Chapter 6 we study the protein product of a highly estrogen-regulated gene, carbonic anhydrase XII and examine the potential for this enzyme to act as an endogenous reporter of estrogen receptor action using imageable inhibitors of this protein.
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