Testosterone, Lycopene Isomers, and Prostate Cancer
Boileau, Thomas William-Maxwell
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Permalink
https://hdl.handle.net/2142/84992
Description
Title
Testosterone, Lycopene Isomers, and Prostate Cancer
Author(s)
Boileau, Thomas William-Maxwell
Issue Date
2001
Doctoral Committee Chair(s)
John W. Erdman, Jr.
Department of Study
Nutritional Sciences
Discipline
Nutritional Sciences
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Date of Ingest
2015-09-25T22:31:14Z
Keyword(s)
Health Sciences, Oncology
Language
eng
Abstract
The objective of the final study was to determine the influence of purified lycopene, tomato powder, and 20% diet restriction on N-methyl-N-nitrosourea (NMU)-testosterone-induced prostate cancer in rats. Survival was analyzed to include only rats that died with adenocarcinomas of the accessory sex glands. Only tomato powder-fed (RR = 0.570; P = 0.009) rats experienced significantly increased survival as compared to placebo beadlet-fed control rats. No significant influences of lycopene beadlet feeding or diet restriction as well as no interactions were noted for accessory sex gland-specific survival. We conclude that tomato powder may contain compounds, in addition to lycopene, which favorably modulate prostate carcinogenesis.
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