Identification and Characterization of Pat-6/actopaxin in Caenorhabditis Elegans Body Wall Muscle
Lin, Xinyi
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https://hdl.handle.net/2142/86656
Description
Title
Identification and Characterization of Pat-6/actopaxin in Caenorhabditis Elegans Body Wall Muscle
Author(s)
Lin, Xinyi
Issue Date
2003
Doctoral Committee Chair(s)
Benjamin D. Williams
Department of Study
Microbiology
Discipline
Microbiology
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biology, Cell
Language
eng
Abstract
In addition, I identified PAT-4/ILK and a novel protein, K10B2.5, as putative binding partners of PAT-6/actopaxin. PAT-6/actopaxin and PAT-4/ILK colocalize in vivo, forming a multi-protein complex with UNC-112. The accumulation of PAT-6/actopaxin in body wall muscle cells requires PAT-4/ILK kinase domain. K10B2.5 binds PAT-6/actopaxin in yeast two-hybrid assays, and also colocalizes with PAT-6/actopaxin to muscle attachment sites.
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