Regulation of Thalamic Neuron Excitability and Intrathalamic Rhythms by Vasoactive Intestinal Peptide
Lee, Sang-Hun
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https://hdl.handle.net/2142/87238
Description
Title
Regulation of Thalamic Neuron Excitability and Intrathalamic Rhythms by Vasoactive Intestinal Peptide
Author(s)
Lee, Sang-Hun
Issue Date
2005
Doctoral Committee Chair(s)
Cox, Charles L.
Department of Study
Molecular and Integrative Physiology
Discipline
Molecular and Integrative Physiology
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biology, Neuroscience
Language
eng
Abstract
I found that VIP selectively increases the excitability of thalamic relay neurons by producing a long-lasting depolarization. These actions lead to antioscillatory actions of VIP on intrathalamic rhythmic activity (Chapter 2). The excitatory and antioscillatory actions of VIP are predominantly mediated by VPAC2 receptors, and are mediated via the cyclic AMP-dependent second messenger system (Chapter 3). In Chapter 4, I describe experiments in which peptide histidine isoleucine (PHI), a closely related peptide to VIP, produces similar actions as VIP. In the chapter 5, I extended my findings regarding VIP actions to the visual thalamus, because my earlier work focused on somatosensory thalamus. I also provide novel data regarding electrophysiological properties of thalamic neurons in dorsal TRN, putative visual TRN. My results suggest that VIP-related peptides depolarize thalamic relay neurons and these actions clearly influence intrathalamic rhythmic activities. These peptides may play a significant role in regulating information transfer through thalamocortical circuits by modulating excitability of thalamocortical neurons.
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