In Vivo Interaction Between Health Food Supplements and Chemotherapeutic Agents on DNA Damage and Cell Production
Trinachartvanit, Wachareeporn
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https://hdl.handle.net/2142/87843
Description
Title
In Vivo Interaction Between Health Food Supplements and Chemotherapeutic Agents on DNA Damage and Cell Production
Author(s)
Trinachartvanit, Wachareeporn
Issue Date
2004
Doctoral Committee Chair(s)
Francis, Bettina M.
Department of Study
Animal Biology
Discipline
Animal Biology
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Health Sciences, Nutrition
Language
eng
Abstract
As expected, both Ara-C and MMS treated mice had DNA and cellular damage. SW, FL, Soy and RM10 were found to cause alterations of DNA and/or cellular damage. SW affected to increase genotoxicity of bone marrow while the increased percentage of reticulocytes was observed. FL and RM10 were found to interact with Ara-C. Either the interaction of FL or RM10 with Ara-C resulted in decreased genotoxicity to bone marrow cells. Soy affected to decrease genotoxicity of erythocytes. These results demonstrate that over-the-counter health supplements can alter of DNA and cause cell damage and can interact with chemotherapeutic agents, and that flow cytometric analysis is a rapid and reliable technique for screening the cytotoxic and genotoxic effects of these products.
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