Applications of quantitative phase imaging for pathology

Sridharan, Shamira

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https://hdl.handle.net/2142/88244 Copy

Description

Title

Applications of quantitative phase imaging for pathology

Author(s)

Sridharan, Shamira

Issue Date

2015-07-15

Director of Research (if dissertation) or Advisor (if thesis)

Popescu, Gabriel

Doctoral Committee Chair(s)

Popescu, Gabriel

Committee Member(s)

• Kajdacsy-Balla, André
• Bhargava, Rohit
• Boppart, Stephen A.

Department of Study

Bioengineering

Discipline

Bioengineering

Degree Granting Institution

University of Illinois at Urbana-Champaign

Degree Name

Ph.D.

Degree Level

Dissertation

Keyword(s)

• quantitative phase imaging (QPI)
• phase contrast
• quantitative diagnosis
• biomarker
• prostate cancer
• colorectal cancer
• recurrence
• scattering
• anisotropy

Abstract

Prostate cancers, which account for 14% of all cancers diagnosed in the United States, and colorectal cancers, which account for 8.2% of all cancers, present a unique set of diagnostic problems [1]. In the case of prostate cancer, overdiagnosis of early-stage disease and poor accuracy at characterizing high-risk disease, especially when diagnosed at the intermediate stage, are major problems. A new prognostic method is thus necessary for improving prostate cancer management. In the case of colorectal cancer, early disease diagnosis is of critical importance for the purpose of reduction in disease-specific death rates. An automated screening tool which identifies cases that warrant further examination by the pathologist would assist in the implementation of a wide-spread screening program. Quantitative phase imaging (QPI) of unstained tissue provides information on the refractive index distribution, or tissue morphology, with nanometer level sensitivity. Subtle morphological changes in both the epithelial and stromal regions of tissue, which are not visible in stained tissue sections used in current pathological settings, can be measured using QPI. Thus QPI would be a valuable addition to current diagnostic pathology.

Graduation Semester

2015-8

Type of Resource

text

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http://hdl.handle.net/2142/88244

Copyright and License Information

Copyright 2015 Shamira Sridharan

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